Let me say, anti-ageing serums are everywhere, and picking the right one feels so overwhelming sometimes. I’ve spent hours reading Amazon customers’ reviews, watching videos, and trying to figure out which brand is really the top. Eventually, I narrowed it down to two big names: Neocutis Bio Serum VS SkinMedica TNS Advanced+ Serum.
At first, I’m not sure which one to try. Both sound super fancy and promise glowing, younger-looking skin. But since I’m all about real results, I decided to test them both—one after the one—to see what works best for me.
In this post, I want to share what I learn while using Neocutis and SkinMedica. I’ll talk about how they feel, how my skin reacts, and most importantly—which one gives me better results.
If you’re trying to pick between these two serums, keep reading. I’ve got the full scoop from a real woman who wants smoother, healthier skin—without all the guesswork.
My Experience with SkinMedica TNS Advanced+ Serum
I started with SkinMedica TNS Advanced+ Serum because I hear so many people talk about it. Honestly, the first thing I notice is the price—it’s not cheap! But since I’ve tried so many things before that didn’t work, I think, why not give this a shot?

I use it every night, and right after I wash my face. The texture feels smooth but also a little sticky at first. It has a weird smell, but I get used to it quickly. What I like most is that it soaks in fast, and I can apply moisturizer on top without any problem.
After two weeks, my skin starts to feel a little softer. Then, after about a month, I see a small glow. Some of my fine lines look less visible, and my skin feels firmer around my cheeks and jawline.
Even better, my makeup goes on smoother. That’s always a good sign. However, I do notice some dryness in certain spots, especially around my nose. So, I make sure to pair it with a good moisturizer.
In the end, SkinMedica helps with firmness and gives my skin a more youthful look. But I still want to see if something else might work even better. That’s when I heard about Neocutis Bio Serum.
My Experience with Neocutis Bio Serum
Next, I try Neocutis Lumiere Bio Serum. Right away, I notice how light and silky it feels on my skin. It’s not sticky at all, and it smells way better than the SkinMedica serum. Honestly, that’s a nice bonus!
I use this one morning and night, just like I did with SkinMedica. After about a week, my skin already feels smoother. Then, by week three, I start seeing a nice glow. My skin looks more even, and the dark spots on my cheeks begin to fade just a little.

One thing I love about Neocutis is how hydrated my skin feels. Even during colder days, I don’t get those dry patches like before. Plus, this serum works well with the rest of my routine—no irritation, no breakouts.
Even though it also costs a lot, I don’t have to use it much. Just one pump covers my whole face, so it lasts longer than I expected.
By the end of the month, I was impressed. My skin feels bouncy, hydrated, and glowy. Not only that, but I feel more confident leaving the house without makeup. That says a lot.
SkinMedica TNS vs Neocutis Bio Serum: Which One Do I Like More?
Now comes the tough question: SkinMedica or Neocutis—who wins?
Both serums are great, and they really do what they promise. But for me, Neocutis is the winner. It gives me better hydration, a smoother texture, and a more even skin tone. It just feels more gentle and calming, especially for my sensitive skin.
That said, SkinMedica is amazing for people who want firmer, lifted skin. If fine lines are your biggest concern, SkinMedica might be your go-to.
But if you want a soft glow, smoother skin, and less dryness, then Neocutis is the better choice.
Final Thoughts: What I Would Tell My Friends
If a friend asks me, “Which one should I buy?” I’d say:
“If your skin needs firming and you don’t mind a serum that feels a little sticky, go for SkinMedica. But if you want something light, hydrating, and gives a healthy glow, try Neocutis. Honestly, you can’t go wrong with either one.”
Want to see which one works best for you?
Shop my favorites below and try them for yourself:
👉 Shop Neocutis Bio Serum here
👉 Shop SkinMedica TNS Advanced+ Serum here
These are affiliate links, which means I may earn a small commission—at no extra cost to you. It helps support my blog and keeps the reviews honest and real. 💕